Why Does My Computer's Setup Program Keep Coming Up?

Probably the CMOS battery died. Everything on a computer is powered by electricity. The setup program holds the computer's hardware configuration in the CMOS (complementary metal-oxide semiconductor) program by battery power.  If the computer is a few years old and an older motherboard was used in it, then the battery probably has died and it's time to replace the battery. They are on the motherboard held in place by a clip. Check with your manufacturer for a replacement. Any time you open up a computer case make sure that you discharge static buildup  by touching the outside of the case.